个体最多有多少种HLA-DR基因?或者说,单个细胞表达多少种MHC II?背景：来自wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3,-4 o -5).That means that one he

个体最多有多少种HLA-DR基因?或者说,单个细胞表达多少种MHC II?背景：来自wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3,-4 o -5).That means that one he
个体最多有多少种HLA-DR基因?或者说,单个细胞表达多少种MHC II?
背景：来自wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3,-4 o -5).That means that one heterozygous individual can inherit 6 or 8 Class-II alleles,three or four from each progenitor.
问1：
wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB4 o -5) or three genes (DRB1 and DRB2 and DRB3) .That means that one heterozygous individual can inherit 6 10 Class-II alleles,5 from each progenitor.
（当同源染色体分别是DR3,DR5,DR6其中之一时,MHC II 基因为10个）
问2：DR2 单体基因型含有B2 和B5基因,细胞会否经过重排最后只有B2 或者B5留在染色体上?另外,HLA的MHC II的3个基因座DP,DQ,DR会否重排最后只留下一个座的基因来翻译MHC II?
问3：
我认为这篇wiki 和这篇nature上用allele这个词没用对
wiki ：one heterozygous individual can inherit 6 or 8 Class-II alleles
nature：DRB1,DRB5 and DQ alleles on DR2 haplotype in Caucasians.
等位基因才是allele,但是DRB1,DRB5 and DQ根本不等位,因此,这两处的 alleles应该用genes来表达,

个体最多有多少种HLA-DR基因?或者说,单个细胞表达多少种MHC II?背景：来自wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3,-4 o -5).That means that one he
HLA-DR 由一个alpha链,一个β链组成.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted.
我在wiki上看到的和你看到的不一样啊：
The genetics of HLA-DR is complex. HLA-DR is encoded by several loci and several 'genes' of different function at each locus. The DR α-chain is encoded by the HLA-DRA locus. Unlike the other DR loci functional variation in mature DRA gene products is absent. (Note: see table Number of Variant Alleles HLA-DR Loci- reduces the potential functional combinations from ~1400 to ~400 (table is not exact because new alleles are continually being added not all new alleles are functional variants of the mature subunits)).
The DR β-chain[2] is encoded by 4 loci, however no more than 3 functional loci are present in a single individual, and no more than two on a single chromosome. Sometimes an individual may only possess 2 copies of the same locus, DRB1*. The HLA-DRB1 locus is ubiquitous and encodes a very large number of functionally variable gene products (HLA-DR1 to HLA-DR17). The HLA-DRB3 locus encodes the HLA-DR52 specificity, is moderately variable and is variably associated with certain HLA-DRB1 types. The HLA-DRB4 locus encodes the HLA-DR53 specificity, has some variation, and is associated with certain HLA-DRB1 types. The HLA-DRB5 locus encodes the HLA-DR51 specificity, which is typically invariable, and is linked to the HLA-DR2 types.
希望这个能解你的答案.